![]() ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.) Filing date Publication date Application filed by Disney Enterprises Inc filed Critical Disney Enterprises Inc Priority to US13/190,624 priority Critical patent/US8490550B2/en Assigned to DISNEY ENTERPRISES, INC. ![]() Original Assignee Disney Enterprises Inc Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.) Shull Current Assignee (The listed assignees may be inaccurate. Crawford Thomas Fitzgerald Derek Howard David A. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Active, expires Application number US13/190,624 Other versions US20130025492A1 Google Patents Roller coaster with articulable seat backsĭownload PDF Info Publication number US8490550B2 US8490550B2 US13/190,624 US201113190624A US8490550B2 US 8490550 B2 US8490550 B2 US 8490550B2 US 201113190624 A US201113190624 A US 201113190624A US 8490550 B2 US8490550 B2 US 8490550B2 Authority US United States Prior art keywords seat ride passenger vehicle seat back Prior art date Legal status (The legal status is an assumption and is not a legal conclusion. Google Patents US8490550B2 - Roller coaster with articulable seat backs US8490550B2 - Roller coaster with articulable seat backs
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![]() But first, let’s have a basic understanding of the two authenticators. To help set them apart and determine which one is more superior to the other, we’ll lock them head-on on multiple accounts by expounding on their shared and dissimilar features. In this in-depth article, we’ll focus on two of the market’s most popular authenticators – Microsoft and Google authenticators. Thankfully, different apps have varying features and capabilities, which you can compare and contrast to go with the most endowed one. Today, the market is full of tons of 2FA authenticator apps, such that choosing the best option can be a tough decision. It is one of the best-proven ways of reducing cybersecurity breaches by providing an additional layer of security in the form of identification, preventing hackers from gaining access to your endpoint devices or sensitive data. In any case, if you've lost access to games or apps, you can contact them directly and they can help you recover the account through a questionnaire based on questions regarding your personal data.Written by Michael Anderson posted on May 26, 2021 You will then need the backup key that the app generates when you first set it up. If you've lost your phone and want to restore Google Authenticator to a new one, you will need to log in to your account with two-factor authentication enabled. How do I restore my Google Authenticator on a new phone? The user enters their username and password into the app, which then generates a six-digit code that changes every 30 seconds. It is an application that generates time-based one-time passwords for the user. Google Authenticator is not an encrypted program. ![]() Google Authenticator can be backed up by exporting the secret key to an argoat. If you don't have a backup, it's not possible to get your Google Authenticator back on a new phone. If you have a backup of your Google Authenticator codes, you can recover your Google Authenticator on a new phone. Can you get Google Authenticator back on a new phone? This code changes every 30 seconds, so it would be impossible for someone else to guess it.īackup codes are generated when you set up Google Authenticator on your device. It generates a six-digit number every 30 seconds, which you must enter when you log into your account. Google Authenticator is a two-step verification system that provides an additional layer of security for your Google account. Where do I find my Google Authenticator backup code? If you lose your phone or change phones, you'll need to return to the account setup page on your PC and generate new security codes. This token changes every 30 seconds and is only valid for one use. Google Authenticator is a two-factor authentication app that generates a time-based token for each login attempt. But yes, when you configure it for the first time, it generates a backup QR code. The answer to this question is a bit complicated, but the short answer is that Google Authenticator does not perform regular backups. Follow the steps to set up Google Authenticator again with a new token. Once you have successfully reset your password, go to and select “Two-Step Verification”. If you haven't already done so, click "Forgot my password?" and follow the steps to reset your password. To reactivate your Google Authenticator, you will need to enter the old token and a new one. Google Play Store: Download the latest updated version for Android How do I reactivate my Google Authenticator? ![]() ![]() We’ll see how the Nintendo handheld handles it in June, it seems. Omori is a notable piece of the indie RPG genre at this point, and definitely seems like a good fit for the Switch. ![]() It has some incredible story beats and design though, and a unique combat system that uses emotions in battle. Omori deals with some fairly heavy subject material, so it’s worth knowing that going in. The hand-drawn style and cheerful aesthetic give way to darker plot beats. If you haven’t seen Omori or the following it’s garnered since its launch in December 2020, it’s a notable one to watch. But all signs point to Omori hitting consoles on June 17. We’ve reached out to MP2 Games, the studio collaborating with Omocat for the port, for additional confirmation. And though it wasn’t certain, the physical version of Omori had originally been slated to ship in June. There’s a similar announcement on the official Omori website, too. while we will still release the digital version of OMORI for consoles on june 17th, to ensure quality, we will be delaying the physical releases by 2 weeks. during testing, we found a small number of issues that needed to be fixed. We’ve been working on porting OMORI to consoles. while we will still release the digital version of OMORI for consoles on june 17th, to ensure quality, we will be delaying the physical releases by 2 weeks.” “we’ve been working on porting OMORI to consoles. Just like the echoes we heard from my test. It’s the same words, cut off at the start. Day 379: The day before we heard the monster, Jason said the words wordhunt and cheat Then we heard the monster say hunt and eat. Developer Omocat also announced the date via Twitter late last week, as spotted by Gematsu: Is Omori out on Switch yet OmoriOnSwitch. Though Omori was the end-of-showcase stinger at last December’s Indie World Showcase, it didn’t appear at all during today’s presentation.īut over on the Nintendo eShop, Omori now has a release date of June 17 in North America. News first started going around when Omori appeared in the Japanese Indie World Showcase this morning, with a launch date of June 17. Both a tweet from the developer and an updated date on the Nintendo eShop indicate Omori is coming to Switch and PS4 on June 17, 2022. It looks like amid all the indie news today, the port of Omori now has a release date. Omori will come to the Nintendo Switch and PS4 in Spring 2022, and the physical copies will appear in June 2022.The adorable, yet dark RPG seems to have a release date On December 25, 2020, the PC version finally appeared. It was first announced back in 2015, with the PC and 3DS as its initial planned platforms. OMORI standard edition for Nintendo Switch and PlayStation 4 is up for preorder! /SkpKVi0TNE The end of the video offers a look at the game’s box art. There’s also a trailer that appeared alongside the Omori physical copy announcement that shows off some of its characters. However, Fangamer’s listing said that it will ship by June 17, 2022. The official Omocat one doesn’t offer any exact dates. The product listings for these physical copies say the retail copies will ship in June 2022. When the first console version of Omori was confirmed for the Switch back in December 2021, it was given a Spring 2022 release window. It will be $34.99.Īlongside the reveal offers another potential hint at a release date. Both Omocat and Fangamer opened up pre-orders for retail copies. When Omori comes to the Nintendo Switch and PS4, a person buying it will be able to decide between a digital or physical copy. ![]() This winter’s track refurbishment ensures The Beast will maintain its spot as one of the best wooden roller coasters in the world for years to come. In fact, its one of only two roller coasters that have been on every top 10 list Amusement Today has published since the inception of the Golden Ticket Awards in 1998. For sheer size, speed and thrills, The Beast stood alone in a class by itself.Ī legend in its own time, you will always find The Beast in the top 10 in just about every annual industry and enthusiast poll for wooden roller coasters. ![]() It took riders to a place they’d never been before, delivering the next level of big thrill, adrenaline-pumping excitement. In roller coasters, there had been nothing else like it anywhere. So high of a resolution, you can easily print posters from them You can. Original photos are size 4032 x 3024 pixels, around 6MB each in size. Our advanced video camera sunglasses have a built in high resolution 12MP camera. The opening of The Beast in 1979 shook the roller coaster world to its very foundations, breaking all existing records as the longest and fastest ride in the world. These Kings Island Haunt photos were all taken using our new daVideo Rikor camera glasses. 1 and is expected to be completed by Mar. In order to simplify the geometry of the crossover, the lower bents will be upper bents until the tunnel. The original design of The Beast had the upper and lower track in the helix on top of each other. With the redesign, the forces through the structure will be more evenly distributed to the foundation, the rigidity of each bent more consistent and therefore resulting in a smoother ride experience. The Beast helix crossover will see a redesign and installation of new bents. This change, along with The Gravity Group’s vertical track design, will deliver a buttery-smooth transition through the tunnel and onto the second drop. ![]() This change isn’t being made to add more speed or thrill element to The Beast, but to come in lower in the tunnel to provide the proper parabolic arcs due to reprofiling of the track in that area of the ride. The first drop will see a change from 45 degrees to 53 degrees. The Gravity Group, which installed 600 feet of its new engineered precut track on the park’s Racer roller coaster last winter, is breathing new life into the ride’s first drop and through the first tunnel and turn towards the second drop and 540-degree helix tunnel, while Kings Island’s carpenters are retracking approximately 1,090 feet of track in other sections along the 7,359-foot long course. "The world’s longest wooden roller coaster, The Beast at Kings Island, is receiving 2,000 feet of track refurbishment this winter. But, this IS a Cartoon Network-distributed show, and thus, it SHOULD measure up to the quality viewers have come to expect from the network. It might not be fair to judge this show so harshly based on the merits of Cartoon Network's other shows it might actually be "decent" if it didn't have other shows of higher quality to measure up to. Aside from the strength of Rodney's character, the other characters on the show are considerably weak. Rodney stands out as one of the only truly influential characters on the show, and possibly the only interesting one, with everything essentially revolving around and hinging upon the actions of this character. The humor is pretty basic and enough to get a laugh or two from kids, but there aren't any cleverly inserted jokes that'll have adults cracking up (unlike "Billy and Mandy" for example). Rodney is the driving force of the show, always imposing his will upon Andy and getting the two of them into trouble. Basically the show's about a boy, Andy, and his squirrel friend/pet, Rodney. The story and gags aren't anything to get excited about, though not terrible, they pale in comparison to some of the other shows on Cartoon Network that are overflowing with charismatic writing. What's the show itself like? How's the writing, the plot? Well, unfortunately, there's no saving grace in the show's writing. ![]() So, the character design style of the show share's Duckman's art-house ugliness (but lacks the twisted humor to go with it), and the two characters around whom the entire show revolves have overused voices. ![]() A good character has a unique look and voice that's the kind of character that kids will remember. It was a bad casting decision to imbue the two main characters on a brand new show with voices that are far from new or unique. True, they're great voice actors, but we've heard these voices before, and have come to identify them with other characters (or likely the actor themselves when the voice is overused enough). The voice of Rodney isn't that much different from other famous characters played by Horvitz, such as Billy (The Grim Adventures of Billy and Mandy), ZIM (Invader ZIM), Dagget (The Angry Beavers), and Kanchome (Zatch Bell, an anime currently shown a LOT on Cartoon Network). Squirrel," also provides a familiar voice. Pamela Adlon, the voice of "Andy" on this show, provides a voice that's quickly identified as the same voice used for Bobby Hill (King of the Hill), Otto (Time Squad), Milo (The Oblongs), and Spinelli (Recess), just to name a few. ![]() The two lead voice actors pull out their tried-and-true voices for this show. Duckman was able to pull it off due to the deranged nature of the show, but it just doesn't hold up in "Squirrel Boy." The voice acting is good, but therein lies another downfall these are voices most cartoon-watchers have heard a LOT and can connect to famous characters from better cartoons. At least the animation is smoother and up-to-date, but that scarcely saves it from its own inherently ugly art-house style. While the grotesque style certainly worked well with a show as bizarre and often disturbing as Duckman, it isn't as effective on a show aimed at kids. Sure enough, he was also the creator of Duckman, a really raunchy and only slightly uglier comedy cartoon for adults. I wondered where I had seen this stomach-churning style of art-house character design before, so I looked up the show's creator, Everett Peck. ![]() One good thing about the two libraries is that they are easy to learn and they require less code as opposed to using libraries in the standard library for scraping. Beautifulsoup is a library for traversing HTML documents for the purpose of extracting data.įor you to know how to effectively use these two for scraping, you will need to read their official guide and documentation. ![]() The Requests library is an HTTP library that provides you with a higher-level API to make sending HTTP requests simple. Both are third-party libraries of Python. In this article, we would be using Python.įor the libraries you should use, the duo of Requests and Beautifulsoup would get the job done. All you need is a programming language that provides you with a way to send HTTP requests and parse out required data from HTML documents. There is no specific programming language that you need to use. Whether you want to collect the database of freelancers or clients or you want to extract job details on Upwork, you can do that with your coding skill. If you have coding skills, you can easily create your own web scraper to collect data from Upwork. Non-coders should go to the next section where we recommend already-made web scrapers they can use for scraping Upwork. If you are a coder, this section has been written for you. Interestingly, these jobs are only a small fragment of the jobs posted on the platform. So in essence, to remain legal while scraping Upwork, you need to access it as a guest which would mean some of the private jobs and invite-only jobs are out of your reach. Fortunately for us, even though Upwork does not support web scraping, the act is not illegal provided you did not log into your account to carry out the act. On the other hand, extracting data manually from hundreds and thousands of web pages is not only inefficient but also time-wasting, boring, and error-prone. In fact, it might interest you to know that Upwork does not support web scrapers extracting data from its web pages and would block you if you are found using web scrapers. This is because Upwork did not provide an API that would provide users with the data on their platform. This is the best method of collecting job data including description, budget, time period, and clients details. It is carried out by web scrapers that are designed to visit the web pages of Upwork, masquerading as regular web browsers to extract data of interest on the web pages. The act of extracting the publicly available data on the Upwork web pages is known as web scraping. One thing you need to know though is that if you are choosing to create your own to avoid spending money then it wouldn’t work as scraping regardless of the route you take would cost you money – and yes, it pays to pay for tools and services that would make you money. If you have the skill and you are ready to develop a custom Upwork scraper from scratch, then we also provided a guide for you to get that done. In this article, we would be discussing some of the best web scrapers you can use for scraping Upwork as not all web scrapers are fit for the job. If you are also interested in extracting the data on Upwork, then you are on the right page. If you take a look at these and many more of the statistics related to Upwork, you will know that the platform is a library of job data provided you know what you are looking for.Īnd as we have come to find out, a good number of people ranging from freelancers and clients to market researchers are scraping Upwork for job data. According to data available, over 3 million jobs are posted yearly. Upwork is one of the largest freelancing platforms in the world with over 5 million registered freelancers and 5 million clients. We also provide a guide on how to create a custom Upwork scraper if you have coding skills. We would be recommending some of the best web scrapers you can use for Upwork. Scraping Upwork can be easy if you use the right tools for the scraping exercise. ![]() I wasn't able to find a lot of good info using a google search so I took it on myself. I have several old Android devices floating around and I've always wanted to use them for more home automation. Instead, I wanted something on my local network. You could even setup to trigger it on email or something as long as you have a device or service that is monitoring and can fire the packet. This is absolutely not the only way of doing this. It could be an arduino or pi, any OS, etc. It doesn't have to be an Android device using these apps and steps. What's cool about the magic packet mechanism is you can make your own app to send the packet from any device on your network really. Also, there are potential security risks if you over-expose certain settings/ports to the outside world beyond your modem or router. It's not that complicated to do and it's free, doesn't require extra hardware/computer to do it unless your modem or PC doesn't support it (2021 I'd be shocked). Plus, depending on how capable the router is, you'll have to possibly fiddle with fixed/static IP addresses or DHCP tables. However, this can be annoying to do and sometimes your ISP will change your IP on you. Most routers can allow you to expose ports and let you hit your PC remotely with a Wake on Lan (or "magic" packet) that will automatically boot your computer. If you just need a fast and easy solution for computer wake up - iNet WOL is perfectly suited for you.I wanted to be able to boot up my PC using Google Assistant or some kind of trigger I could also do manually and remotely. INet WOL is also included in our network scanner iNet, alongside with other network tools like ping, Bonjour scanner, portscan and more. Wake On Lan currently works within the same subnet. ![]() We will implement this feature in a future update. Wake On Lan with subnet directed broadcasts is not supported in version 1.0. Router and firewall must be configured correctly.Router must be capable of forwarding wol packages.The network must be reachable via internet.Network cards must support the standard Magic Packet format.Īdditional prerequitsites for WOL via internet:.Computers must be configured correctly for wake on lan.Computer and router are connected via ethernet cable.iPhone/touch have to be in the same subnet.iPhone/touch has to be connected to your lan.Its that simple.įor more detailed setup instructions regarding wake on lan via internet please see our website. Start iNet WOL and click on the device you want to wake up. Just click on an item in the generated list to add it to your favourites. You do not need to find out the MAC addresses or type them in. INet WOL scans the devices connected to your local network and shows them along with their name, IP and vendor at the tip of a button. Add new devices with one touch (need to enter MAC address since iOS 11).Sleep, shutdown or reboot a computer remotely (Mac OSX only at the moment).Wake computer on the local network from sleep.Its outstanding feature is its easiness of usage and the simple setup process. INet WOL is a tool to wake computer from sleep via a local network or the internet. or Android KitKat 4.4, Lollipop 5.0, Marshmallow 6.0, Nougat 7.0, Oreo 8.0, Android Pie 9.0, Quince Tart 10, Red velvet cake 11, Snow cone 12 or later versions Compatibility: Requires iOS 10.3 or later. You’ll still get a bargain with it, though. Too bad the price-tag isn’t particularly user-friendly. Together, they make the Xprite sleeping mattress incredibly sturdy and tear-resistant. ![]() It’s an excellent combination of high-density foam, synthetic leather, and superior thread cloth. Material quality deserves our attention as well. In addition, the company made it easily removable and washable. So, what does it have to offer with this mattress? Well, it is very easy to fold up and to fold out, which can’t be said about most rivaling products. Xprite is a big, respected brand on the market of third-party Jeep accessories. The last portable mattress on today’s list is also the most expensive one. Xprite Portable Foldable Sleeping Mattress While it’s low-priced and resistant to pretty much everything nature can throw its way, this air mattress comes with a towel, patches, and a storage bag!ģ. ![]() Looking for an affordable, capable, and water-proof camping mattress for your Jeep? Pavoni might have just the right deal for you. And, above all, the price-tag for this lovely package is more than reasonable. You’ll get a towel, a storage bag (it’s not of the best quality, but decent), and a couple of repair patches for stitching up the mattress. Instead of include a standard pump, Pavoni packs its air mattress with a mighty list of extras. I also want to mention the generous package. That’s right: you can use it not only inside of your Jeep or in a tent, but also the closest pool. Along with that, it’s also 100% odorless (a good thing if you camp a lot, especially with pets) and cold-resistant. Just like the previous air mattress by Wey and Fly, the one by Pavoni is soft, made from high-quality materials, and durable. It includes a 12V air pump for inflation and will ensure a cozy night under the stars for you and your family out in the wilderness. Highly customizable, thick, protected against temperature extremes, and with a superior weight capacity – that’s the Wey & Fly air mattress in short for you. But don’t worry: it won’t go out of air overnight. My only complaint: when under high pressure, this mattress loses air faster than most rivals. That gives you a lot of room for “maneuvers” and allows adjusting the mattress to reach the highest level of comfort. I’m talking about fully pumped, as well as partially inflated (60% or 40%). On top of that, the Wey & Fly engineers created an impressive inflation system that comes with three different modes. It can hold up to 570 pounds/260 kilograms of weight – that means you, your spouse, a kid, and even a dog/cat. Another standout feature is the market-leading weight capacity. It is breathable, soft to touch, and “handles” a wide temperature range (-13 to +122 degrees F.).
![]() If you witness unauthorized bib selling or cheating in any form, please report the activity. *UPDATE – For the third consecutive year, for 2019, Marathon Investigation is working with CIM as their results verification partner. I am proud to be associated with this great event. As part of our agreement, I will serve on The CIM Results Committee in the role of Results Verification Partner. As a Platinum Level partner, CIM is showing the highest level of commitment in taking a stand against cheating. ![]() Partnership With Marathon InvestigationĪs announced earlier this week, CIM and Marathon Investigation have entered into a formal partnership. More recently, a runner was apprehended by local police on Disneyland property after fraudulently obtaining another runner’s bib. The Miami Marathon race director reported catching over 200 bandits as they approached the finish line. There have been recent high profile examples of races having to devote significant effort to deal with cheating and bandits. Whenever a race is forced to turn their attention to cheating, that is time they are not able to devote to other aspects of the race. It is unfortunate that races have to take these steps, and that they have to spend their time dealing with bib sellers, bib mules, course cutters and bandits. The race confirmed that the runner was specifically looking for a buyer to run a BQ time. This runner was giving his bib away in the attempt to run a specific time. It should be made very clear that this wasn’t the case of someone trying to offload a bib when they were injured or just unable to run a race. One commentor on Facebook felt that the punishment seemed harsh for selling a bib. The race would consider a reduction of the ban down to 3 years if the runner fully cooperates with their investigation. Beyond that we will keep your personal information confidential (although we reserve the right to change that stance if your future actions necessitate it). Additionally, the Sacramento Running Association will be sharing your information with Marathon Investigation, which maintains a flagged list of runners whose results deserve further scrutiny, as well as other running organizations including many major races in our region as well as the Boston Athletics Association, organizers of the Boston Marathon. I n light of this, your entry for this year’s California International Marathon has been invalidated and you are banned from future editions of the California International Marathon. It is unethical and wrong, and could result in robbing someone of a spot on the Boston Marathon starting line–a spot that they fairly earned. … Beyond being a clear violation of event rules, paying a bib mule to run a Boston Qualifier for you goes even several steps further–it compromises the integrity of our event and its results, is intentional and premeditated cheating, and goes against the very spirit of the marathon. The letter revealed that the runner has been banned from participating in the 2017 CIM as well as all future editions of CIM. ![]() Through their website, the race shared their response: The post came to the attention of race director, Eli Asch. Electron microscopy revealed swelling of the endothelial cells (Fig. An immunofluorescence study did not show deposition of immunoglobulin or its complement. However, spike formation was not evident in the periodic acid-methenamine silver-stained section test (Fig. A percutaneous kidney biopsy was performed, and light microscopy with periodic acid-Schiff staining revealed diffuse and global endothelial cytoplasm expansion that was accompanied by focal duplication of the glomerular basement membrane (Fig. Ultrasonography showed that the kidneys were almost normal-sized. Urine sediment showed 5–9 red blood cells/high-power field and hyaline casts. ![]() A spot urine examination showed protein/creatinine ratio of 12.2 g/gCr, urinary protein 3+, and hematuria 1+. In addition, antinuclear antibody and viral hepatitis were not evident in a serological test. Blood chemistry and serology tests showed a serum creatinine level of 0.87 mg/dL (estimated glomerular filtration rate of 78.4 mL/min/1. 73m 2), serum albumin level of 3.08 g/dL, total cholesterol level of 287 mg/dL, and low-density lipoprotein cholesterol level of 166 mg/dL. A complete blood count test showed a white blood cell count of 11,500/μL, hemoglobin level of 13.2 g/dL, and platelet count of 132,000/μL. On admission, a physical examination showed a blood pressure of 121/70 mmHg, pulse of 56/min, temperature of 36.5☌, and respiratory rate of 16/min, as well as slight splenomegaly and lower leg edema. The patient was referred to our hospital for a further investigation for nephrotic syndrome after dasatinib was used for 3 months. Two months after dasatinib was introduced, the drug was transiently stopped because of pancytopenia, and then the drug was restarted. However, 1 month after dasatinib was introduced, heavy proteinuria (urinary protein-creatinine ratio of 8.93 g/g creatinine ) appeared, accompanied by a low serum albumin level of 2.3 g/dL. According to a bone marrow examination, he was diagnosed with CML, and dasatinib at a daily dose of 100 mg was prescribed.ĬML was improved with the use of dasatinib therapy, with a decreased volume of splenomegaly and leg edema. A blood test showed an elevated white blood cell count of 480,000/μL. The patient’s leg edema was thought to be caused by the giant splenomegaly. A physical examination showed a giant splenomegaly that reached the pelvic cavity and hepatomegaly. Here, we report the case of a CML patient in whom nephrotic syndrome was induced by dasatinib, along with a short literature review.Ī 40-year-old Japanese man was admitted to another hospital with edema of both lower extremities, a feeling of abdominal fullness, and shortness of breath upon exertion. However, recent reports suggested that renal adverse effects, including nephrotic syndrome, could occur after TKIs are used. Dasatinib, a second-generation TKI, is available in Japan and leads to a higher remission rate of CML than former-generation TKIs do. Therefore, tyrosine kinase inhibitors (TKIs) are known to be“silver bullet” therapies that dramatically improve the prognosis of patients with CML. The BCR-ABL gene is formed by mutual translocation between c-ABL on chromosome 9 and BCR on chromosome 22, which activates tyrosine kinase continuously, leading to leukemia-cell proliferation. CML slowly progresses in the first 4–6 years after onset, but when it progresses to the blastic stage, it is acute and lethal. Conclusionsĭrug-related nephrotic syndrome should be considered when nephrotic syndrome develops during treatment with dasatinib.Ĭhronic myelogenous leukemia (CML) is an important hematological tumor that is characterized by the BCR-ABL chimera gene and occurs in 15 to 20% of adults with leukemia. The patient was discharged from our department on the 25th day after hospitalization, without any drug aftereffects. Switching from dasatinib to nilotinib led to a decrease in the proteinuria level, from 12 to 0.6 g/g creatinine, within 2 weeks. Additionally, in an electron microscopy study, randomly arranged fibrils were observed in the mesangial and subendothelial regions. A percutaneous kidney biopsy was performed, diffuse glomerular endothelial injury and effacement of the foot process were noted, and the patient was diagnosed with dasatinib-induced nephrotic syndrome. Case presentationĪ 40-year-old man with chronic myeloid leukemia was referred to our hospital because of proteinuria 1 month after dasatinib therapy was introduced. Here, we report the case of a man with nephrotic syndrome that was caused by dasatinib. Dasatinib is a second-generation tyrosine kinase inhibitor that is indicated for the treatment of patients with chronic myeloid leukemia. |